microRNA - Wikipedia - mature mirna

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Real-time PCR quantification of precursor and mature microRNA mature mirna


The mature miRNA is part of an active RNA-induced silencing complex (RISC) containing Dicer and many associated proteins. RISC is also known as a microRNA ribonucleoprotein complex (miRNP); A RISC with incorporated miRNA is sometimes referred to as a "miRISC." Dicer processing of the pre-miRNA is thought to be coupled with unwinding of the duplex.

Feb 11, 2016 · TL,DR: Essentially pri-miRNA, pre-miRNA are components of the biogenesis pathway for the mature miRNA. microRNAs (miRNA) are small, non-coding RNAs that mediate gene silencing through binding to the 3' untranslated region (3'UTR) of their target g.

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miRNA Biogenesis. miRNA Pathway. The genes encoding miRNAs are much longer than the processed mature miRNA molecule. Many miRNAs are known to reside in introns of their pre-mRNA host genes and share their regulatory elements, primary transcript, and have a similar expression profile.