A sperm granuloma is a lump of extravasated sperm that appears along the vasa deferentia or epididymides in vasectomized men. Sperm granulomas are rounded or irregular in shape, one millimeter to one centimeter or more, with a central mass of degenerating sperm surrounded by tissue containing blood vessels and immune system cells.
Sep 11, 2019 · A sperm granuloma is an infection caused by sperm leaking into the scrotum during a vasectomy or vasectomy reversal. Successful reversal is more likely when there has been a granuloma following vasectomy. Those who have had a granuloma following a vasectomy reversal frequently have sperm antibodies, but these have not been shown to affect fertility.
Sperm granulomas are composed of a central mass of spermatozoa, some of which are degraded, surrounded by radially arranged epitheloid macrophages and multinucleated giant cells, granulation tissue, lymphocytes, and plasma cells (McDonald and Scotome, 1987).
Aug 19, 2014 · Sperm granulomas occur when sperm is released into the interstitium through a rupture in the epithelial lining or when inflammatory cells gain access to the sperm within the ductular lumen. If there is rupture into the interstitium, the epididymal lining may repair itself and maintain sperm continuity through the epididymal duct.